KMID : 0361520060170050456
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Korean Journal of Psychopharmacology 2006 Volume.17 No. 5 p.456 ~ p.460
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The Bipolar Diathesis in Patients with Treatment Resistant Depression
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¿ì¿µ¼·/Woo YS
äÁ¤È£/¼È£ÁØ/¼ÛÈĸ²/ÀüÅ¿¬/±è±¤¼ö/¹Ú¿ø¸í/Chae JH/Seo HJ/Song HR/Jun TY/Kim KS/Bahk WM
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Abstract
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Objective : In this study, we determined the prevalence of bipolarity in patients with treatment resistant depression (TRD) by investigating demographic and clinical characteristics, diagnostic subtypes, and illness outcome.
Method : A medical record review of patients admitted to a university hospital with the diagnosis of major depressive disorder (MDD) was conducted. DSM-¥³ diagnoses at index hospitalization and six months after discharge and detailed clinical information were obtained. We categorized subjects into a TRD group or a non-TRD group and re-evaluated the patients using the recently proposed criteria for bipolar spectrum disorder (BSD). Patients in the TRD group were compared with patients in the non-TRD group with regard to the prevalence rate of BSD at the index hospitalization and at the end of the follow up period.
Results : There were 281 patients diagnosed as MDD. At discharge, the number of patients who fulfilled the criteria for BSD was higher (p£¼.001) in the TRD group (32/68, 47.1%) than in the non-TRD group (8/213, 3.8%). At the end of six-month follow-up period, the diagnoses of 38 patients changed ; 18 (26.5%) in the TRD group were subsequently classified as having bipolar disorder, and seven (3.3%) in the non-TRD group (p£¼0.001). There was no difference between these two groups in other clinical and demographic variables.
Conclusion : The findings suggest that a large number of patients with TRD have a bipolar diathesis.
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